ARONVIS Technical Information
Features
① Consistent viscosity upon dissolution with minimal change over time
② Maintains excellent adhesion
Development Concept
Relationship Between Concentration and Viscosity
ARONVIS is a polyelectrolyte. When dissolved in water, sodium ions dissociate from the polymer structure, leaving the polymer ions with numerous negative charges. Interactions between positive and negative charges extend the molecules and produce a thickening effect. Higher ARONVIS concentrations result in higher viscosity.
The viscosity of ARONVIS aqueous solutions is affected only slightly by pH changes under alkaline conditions, but is significantly affected by pH under acidic conditions.
Comparison with Previous Products
Solubility Comparison
[Test Method] Initial dissolution viscosity at 0.2%: Add 0.3 g of ARONVIS to 10 g of glycerin, stir for 30 seconds, add 140 g of water, and measure viscosity after 15 seconds, 10 minutes, and 20 minutes.
ARONVIS SX
ARONVIS MX
ARONVIS AH-105X
| Mw | Mn | Mw/Mn | |
|---|---|---|---|
| AH-105 | 2,400,000 | 261,000 | 9.20 |
| AH-105X | 2,870,000 | 720,000 | 3.99 |
Particle-Size Distribution Comparison
| Improved Grade | Current Grade | ||
|---|---|---|---|
| Particle Size (Reference) | Grade | Grade | Particle Size (Reference) |
| 850～212μm | GLX | GL | 850～355μm |
| 300 μm or Less | SX | S | 355～125μm |
| SS | 125 μm or Less | ||
| 300 μm or Less | MX | M | 355～125μm |
| MS | 180 μm or Less | ||
| 300 μm or Less | AHX | AH | 250 μm or Less |
| 180 μm or Less | AH-105X | AH-105 | 180 μm or Less |
Standards
| Improved Grade | Current Grade | Applicable Standards and Other Official Documents |
|---|---|---|
| GLX、SX | GL、S、SS | “Sodium Polyacrylate” under the Pharmaceutical Excipients Standard and Standards for Ingredients of Quasi-drugs |
| MX | M、MS | “Sodium Polyacrylate” under the Pharmaceutical Excipients Standard and Standards for Ingredients of Quasi-drugs |
| AHX | AH | “Partially Neutralized Polyacrylic Acid” under the Pharmaceutical Excipients Standard and “Sodium Polyacrylate” under the Standards for Ingredients of Quasi-drugs |
| AH-105X | AH-105 | “Partially Neutralized Polyacrylic Acid” under the Pharmaceutical Excipients Standard and “Polyacrylate” under the Standards for Ingredients of Quasi-drugs |
| AH-106X | AH-106 | “Partially Neutralized Polyacrylic Acid” under the Pharmaceutical Excipients Standard and “Polyacrylate” under the Standards for Ingredients of Quasi-drugs |
Formulation Examples
ARONVIS SX ／GLX
| Raw Material | Parts |
|---|---|
| ARONVIS SX and GLX | 5 |
| JURYMER AC-10H※1 | 10 |
| CMC-Na (Sodium Carboxymethyl Cellulose)※2 | 3 |
| Glycinal (Aluminum Glycinate) | 0.1 |
| EDTA-Na | 0.05 |
| Glycerin | 30 |
| Tartaric Acid | 0.3 |
| Titanium Dioxide | 1 |
| Methyl Paraben | 0.1 |
| Purified Water | 50.45 |
| Total | 100 |
① Gel Evaluation: Curability (Viscoelasticity Analyzer)）
ARONVIS SX/GXL provides better initial curability than the previous product ARONVIS S.
② Adhesion Property Evaluation (After 1 Month)
Peel Strength (against Phenolic Resin), Initial Rolling-Ball Tack, and Shear Strength
Test results show that ARONVIS SX/GLX provides higher shear strength than the previous product ARONVIS S, while peel strength and initial rolling-ball tack are essentially equivalent.
ARONVIS MX
| Raw Material | Parts |
|---|---|
| ARONVIS MX | 6 |
| JURYMER AC-10H※1 | 10 |
| CMC-Na (Sodium Carboxymethyl Cellulose)※2 | 3 |
| Glycinal (Aluminum Glycinate) | 0.12 |
| EDTA-Na | 0.06 |
| Glycerin | 30 |
| Tartaric Acid | 0.3 |
| Titanium Dioxide | 1 |
| Methyl Paraben | 0.1 |
| Purified Water | 49.42 |
| Total | 100 |
*2 Daicel Chemical Industries, Ltd., Product No. 1110
① Gel Evaluation: Curability (Viscoelasticity Analyzer)）
ARONVIS MX provides better curability than the existing product ARONVIS M.
② Adhesion Property Evaluation (After 1 Month)
Peel Strength (against Phenolic Resin), Initial Rolling-Ball Tack, and Shear Strength
ARONVIS MX provides performance essentially equivalent to the existing product ARONVIS M.
ARONVIS AHX
| Raw Material | Parts |
|---|---|
| ARONVIS AHX | 5 |
| JURYMER AC-10H※1 | 10 |
| CMC-Na (Sodium Carboxymethyl Cellulose)※2 | 3 |
| Glycinal (Aluminum Glycinate) | 0.1 |
| EDTA-Na | 0.05 |
| Glycerin | 30 |
| Tartaric Acid | 0.3 |
| Titanium Dioxide | 1 |
| Methyl Paraben | 0.1 |
| Purified Water | 50.45 |
| Total | 100 |
*1 Polyacrylic acid manufactured by Nippon Pure Chemical Co., Ltd.
*2 Daicel Chemical Industries, Ltd., Product No. 1110
① Gel Evaluation: Curability (Viscoelasticity Analyzer)）
ARONVIS AHX provides better initial curability than the previous product ARONVIS AH.
② Adhesion Property Evaluation (After 1 Month)
Peel Strength (against Phenolic Resin), Initial Rolling-Ball Tack, and Shear Strength
ARONVIS AHX provides performance essentially equivalent to ARONVIS AX.
ARONVIS AH-105X
| Raw Material | Parts |
|---|---|
| ARONVIS AH-105X | 5.6 |
| JURYMER AC-10LHP※1 | 1 |
| CMC-Na (Sodium Carboxymethyl Cellulose)※2 | 1.5 |
| Aluminum Hydroxide | 0.02 |
| Glycinal (Aluminum Glycinate) | 0.05 |
| Glycerin | 30 |
| Tartaric Acid | 0.15 |
| Titanium Dioxide | 0.6 |
| Methyl Paraben | 0.1 |
| Purified Water | 60.98 |
| Total | 100 |
*1 Polyacrylic acid manufactured by Nippon Pure Chemical Co., Ltd.
*2 Daicel Chemical Industries, Ltd., Product No. 1110
① Gel Evaluation: Curability (Viscoelasticity Analyzer)）
ARONVIS AH-105X provides better curability than the existing product ARONVIS AH-105.
② Adhesion Property Evaluation (After 1 Month)
Peel Strength (against Phenolic Resin), Initial Rolling-Ball Tack, and Shear Strength
Compared with the existing ARONVIS AH-105, ARONVIS AH-105X provides higher shear strength and equivalent or better peel strength and initial rolling-ball tack.
ARONVIS AH-106X
| Raw Material | Parts |
|---|---|
| ARONVIS AH-106X | 5.6 |
| JURYMER AC-10LHP※1 | 1 |
| CMC-Na (Sodium Carboxymethyl Cellulose)※2 | 1.5 |
| Aluminum Hydroxide | 0.02 |
| Glycinal (Aluminum Glycinate) | 0.05 |
| Glycerin | 30 |
| Tartaric Acid | 0.15 |
| Titanium Dioxide | 0.6 |
| Methyl Paraben | 0.1 |
| Purified Water | 60.98 |
| Total | 100 |
*1 Polyacrylic acid manufactured by Nippon Pure Chemical Co., Ltd.
*2 Daicel Chemical Industries, Ltd., Product No. 1110
① Gel Evaluation: Curability (Viscoelasticity Analyzer)）
ARONVIS AH-106X provides better curability than the existing product ARONVIS AH-106.
② Adhesion Property Evaluation (After 1 Month)
Peel Strength (against Phenolic Resin), Initial Rolling-Ball Tack, and Shear Strength
Compared with the existing ARONVIS AH-106, ARONVIS AH-106X provides higher shear strength and essentially equivalent peel strength and initial rolling-ball tack.
Test Methods
Viscoelasticity Analyzer
Peel Strength Test
Test Conditions
Adherend: Bakelite (Phenolic Resin)
Pressing Conditions: 360 g, 1 kg reciprocating roller
Tensile Speed: 300 ± 30 mm/min
Bonded Area: 2 in × 150 mm
Bonding Time: 30 min, 24 hr
Load Cell: 1–5 kgf
Number of Measurements: n=2
Shear Strength
Test Conditions
Adherend: SUS304
Pressing Conditions: 360 g reciprocating roller
Tensile Speed: 30 mm/min
Bonded Area: 1 in × 1 in
Bonding Time: 30 min
Load Cell: 1–5 kgf
Number of Tests: n=2
Initial Rolling-Ball Tack
Tested in Accordance with JIS Z 0237
Summary
The ARONVIS X series provides excellent, well-balanced performance
a) Gel Strength
b) Adhesion
c) Shear Strength
Excellent machine compatibility and operability
a) Initial Dissolution Viscosity
b) Flowability
c) Shape Retention